Dopamine exerts activation dependent modulation of spinal locomotor circuits in the 5 neonatal mouse
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چکیده
1 2 3 4 Dopamine exerts activation dependent modulation of spinal locomotor circuits in the 5 neonatal mouse 6 7 8 Jennifer M Humphreys and Patrick J Whelan 9 10 Hotchkiss Brain Institute, Departments of Comparative Biology and Experimental Medicine, 11 Physiology and Pharmacology and Clinical Neurosciences. University of Calgary, Calgary, 12 Alberta, Canada. 13 14 15 16 Running Head: Dopaminergic modulation of locomotor networks is activity dependent 17 Correspondence: 18 19 Corresponding Author 20 Dr. Patrick Whelan 21 HS 2119 22 University of Calgary 23 Calgary, Alberta T2N 4N1 24 Phone (403) 220-4210 25 Email [email protected] 26 27 28 Author Contributions 29 Dr. Patrick Whelan conceived and designed the experiments with assistance from Jennifer 30 Humphreys. Jennifer Humphreys collected, and analyzed the data. Both Dr. Patrick Whelan and 31 Jennifer Humphreys contributed to the writing and editing of the manuscript. 32 33 34 35 Articles in PresS. J Neurophysiol (September 19, 2012). doi:10.1152/jn.00482.2012
منابع مشابه
Dopamine exerts activation-dependent modulation of spinal locomotor circuits in the neonatal mouse.
Monoamines can modulate the output of a variety of invertebrate and vertebrate networks, including the spinal cord networks that control walking. Here we examined the multiple changes in the output of locomotor networks induced by dopamine (DA). We found that DA can depress the activation of locomotor networks in the neonatal mouse spinal cord following ventral root stimulation. By examining di...
متن کاملTitle: Dopaminergic Modulation of Locomotor Network Activity in the Neonatal Mouse Spinal Running Title: Dopaminergic Modulation of Locomotion Introduction
19 20 Dopamine is now well established as a modulator of locomotor rhythms in a variety of 21 developing and adult vertebrates. However, in mice while all five dopamine receptor subtypes 22 are present in the spinal cord it is unclear which receptor-subtypes modulate the rhythm. 23 Dopamine receptors can be grouped into two families – the D 1/5 receptor group and the D 2/3/4 24 group that have ...
متن کاملModulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord.
Recently, it has been shown that bath-applied 5-HT can elicit fictive locomotion from perinatal mouse preparations. Since 5-HT acts on multiple receptor subtypes, the focus of this study was to examine which receptor families contribute to the genesis and modulation of locomotor activity. Blockade of 5-HT(2) (ketanserin or N-desmethylclozapine) or 5-HT(7) receptors (SB-269970) could reversibly ...
متن کاملDopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord.
Dopamine is now well established as a modulator of locomotor rhythms in a variety of developing and adult vertebrates. However, in mice, while all five dopamine receptor subtypes are present in the spinal cord, it is unclear which receptor subtypes modulate the rhythm. Dopamine receptors can be grouped into two families-the D1/5 receptor group and the D2/3/4 group, which have excitatory and inh...
متن کاملTTX-Resistant NMDA Receptor-Mediated Membrane Potential Oscillations in Neonatal Mouse Hb9 Interneurons
Conditional neuronal membrane potential oscillations have been identified as a potential mechanism to help support or generate rhythmogenesis in neural circuits. A genetically identified population of ventromedial interneurons, called Hb9, in the mouse spinal cord has been shown to generate TTX-resistant membrane potential oscillations in the presence of NMDA, serotonin and dopamine, but these ...
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تاریخ انتشار 2012